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KMID : 0356720150310030092
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Journal of the Korean Society of Coloproctology
2015 Volume.31 No. 3 p.92 ~ p.97
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ERCC1 as a Predictive Marker for FOLFOX Chemotherapy in an Adjuvant Setting
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Kim Chee-Young
Seo Sang-Hyuk
An Min-Sung
Kim Kwang-Hee
Bae Ki-Beom
Hwang Jin-Won
Kim Ji-Hyun
Kim Bo-Mi
Kang Mi-Seon
Oh Min-Kyung
Hong Kwan-Hee
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Abstract
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Purpose
The purpose of this study was to identify the excision repair cross-complementation group 1 (ERCC1) as a predictive marker for FOLFOX adjuvant chemotherapy in stages II and III colon cancer patients.
Methods
A total of 166 high risk stages II and III colon cancer patients were retrospectively enrolled in this study, and data were collected prospectively. They underwent a curative resection followed by FOLFOX4 adjuvant chemotherapy. We analyzed ERCC1 expression in the primary colon tumor by using immunohistochemical staining. The oncological outcomes included the 5-year disease-free survival (DFS) rate. The DFS was analyzed by using the Kaplan-Meier method with the log-rank test. A Cox proportional hazard model was used for the prognostic analysis.
Results
ERCC1-positive expression was statistically significant in the older patients (P = 0.032). In the multivariate analysis, the prognostic factors for DFS were female sex (P = 0.016), N stage (P = 0.009), and postoperative carcinoembryonic antigen level (P = 0.001), but ERCC1 expression was not a statistically significant prognostic factor for DFS in the univariate analysis (P = 0.397). The 5-year DFS rate was not significantly associated with the ERCC1 expression in all patients (P = 0.396) or with stage III disease (P = 0.582).
Conclusion
We found that ERCC1 expression was not significantly correlated with the 5-year DFS as reflected by the oncologic outcomes in patients with high-risk stages II and III colon cancer treated with FOLFOX adjuvant chemotherapy.
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KEYWORD
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Colon neoplasms, FOLFOX, ERCC1
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